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Article
Renal Infarcts—A Perplexing Case in the Middle of the COVID-19 Pandemic
Frontiers in Pediatrics
  • Brett Plouffe, Schulich School of Medicine & Dentistry
  • Tamara Van Hooren, Schulich School of Medicine & Dentistry
  • Michelle Barton, Schulich School of Medicine & Dentistry
  • Nancy Nashid, Schulich School of Medicine & Dentistry
  • Erkan Demirkaya, Schulich School of Medicine & Dentistry
  • Kambiz Norozi, Schulich School of Medicine & Dentistry
  • Irina Rachinsky, Schulich School of Medicine & Dentistry
  • Johan Delport, Western University
  • Michael Knauer, Western University
  • Soumitra Tole, Schulich School of Medicine & Dentistry
  • Guido Filler, Schulich School of Medicine & Dentistry
Document Type
Article
Publication Date
5-14-2021
URL with Digital Object Identifier
10.3389/fped.2021.669453
Abstract

Renal infarction is a rare finding in children. Associations between SARS-CoV-2 infections and thromboembolic events including renal infarcts have been described in adults. Although a similar association in children has not yet been described with this pandemic, the pediatric literature is still evolving with the recognition of new manifestations including the post-infectious Multisystem Inflammatory Syndrome in Children (MIS-C). We report the rare event of multiple renal infarcts in a 6-year-old boy manifesting several features of MIS-C 9 weeks following a self-limiting febrile illness characteristic of COVID-19. An underlying Factor V Leiden mutation was identified in this child but felt to be insufficient on its own to explain his clinical presentation. As SARS-CoV-2 testing was delayed, the failure to identify viral RNA or antibodies may not exclude the virus' potential role in precipitating the infarct in this host. Given that renal infarcts have been described in adult patients with COVID-19, reporting this perplexing case where SARS-CoV-2 may have played a role, may help identify this potential complication.

Citation Information
Brett Plouffe, Tamara Van Hooren, Michelle Barton, Nancy Nashid, et al.. "Renal Infarcts—A Perplexing Case in the Middle of the COVID-19 Pandemic" Frontiers in Pediatrics Vol. 9 (2021)
Available at: http://works.bepress.com/soumitra-tole/10/