Healthcare workers are being exposed to hazardous drugs during preparation and administration of chemotherapy. This has been an ongoing concern for years in the healthcare industry. Various studies showing contamination in the preparation area, long-term chromosomal abnormalities, biologic marker changes in workers, long-term effects on reproduction, hair loss, rashes, miscarriages, birth defects, and cancers due to chemotherapy exposure make this concern legitimate. There are guidelines for safe handling of both IV and oral chemotherapy from the American Society of Health-System Pharmacists (ASHP), the Oncology Nursing Society (ONS), and the Occupational Safety and Health Administration (OSHA), all of which discuss how to prepare, handle, and administer chemotherapy safely.