Oral chemotherapy has revolutionized oncology, yet with great advancement comes challenges. Oral chemotherapy medication adherence is a challenge for many patients and caregivers for many reasons, including side effects, finances, and lack of education and resources. Medication adherence is crucial in oncology to delay disease-free survival and progression-free survival. Pharmacists can help play a large role in educating patients and assisting them with issues related to oral chemotherapy. This article will discuss review papers and guidelines for oral chemotherapy adherence techniques, the role of the pharmacist, and resources to promote oral chemotherapy adherence.