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Article
Modeling Bistable Cell-Fate Choices in the Drosophila Eye: Qualitative and Quantitative Perspectives
Development (2010)
  • T.G. Graham
  • S.M. Ali Tabei, University of Northern Iowa
  • Aaron R. Dinner, The University of Illinois at Chicago
  • J. Rebay
Abstract
A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and discuss how mathematical modeling can be used to understand and predict the bistable or multistable behavior of such networks.
Disciplines
Publication Date
2010
DOI
10.1242/dev.044826.
Citation Information
T.G. Graham, S.M. Ali Tabei, Aaron R. Dinner and J. Rebay. "Modeling Bistable Cell-Fate Choices in the Drosophila Eye: Qualitative and Quantitative Perspectives" Development Vol. 137 Iss. 14 (2010) p. 2265 - 2278
Available at: http://works.bepress.com/sm-tabei/9/