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Article
Model for Competition from Self During Passive Immunization, with Application to Broadly Neutralizing Antibodies for HIV.
Vaccine (2011)
  • S. M. Ali Tabei, University of Northern Iowa
  • Y. Li
  • M. Weigert
  • Aaron R. Dinner, University of Chicago
Abstract
We propose a mathematical model to interpret observations concerning the behavior of broadly neutralizing antibodies for chronic HIV in vivo. The model enables us to identify a threshold antibody level that must be achieved to decrease the viral load effectively. Although this threshold has not been reached in existing passive immunization studies, it is within range of humoral immune responses, suggesting that therapeutic vaccines are feasible. In an appendix, we develop a model of passive immunization against influenza, and acute infection.
Disciplines
Publication Date
November 23, 2011
DOI
10.1016/j.vaccine.2011.11.048.
Citation Information
S. M. Ali Tabei, Y. Li, M. Weigert and Aaron R. Dinner. "Model for Competition from Self During Passive Immunization, with Application to Broadly Neutralizing Antibodies for HIV." Vaccine Vol. 30 Iss. 3 (2011) p. 607 - 613
Available at: http://works.bepress.com/sm-tabei/6/