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Article
The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eepsilon4 carriers and non-carriers
ECU Publications Pre. 2011
  • Hamid Sohrabi
  • Kristyn Bates, Edith Cowan University
  • Mark Rodrigues, Edith Cowan University
  • Kevin Taddei, Edith Cowan University
  • Georgia Martins, Edith Cowan University
  • Simon Laws, Edith Cowan University
  • Nicola Lautenschlager
  • Satvinder Dhaliwal
  • Jonathan Foster, Edith Cowan University
  • Ralph Martins, Edith Cowan University
Publication Date
1-1-2009
Document Type
Journal Article
Publisher
IOS Press
Faculty
Computing, Health and Science
School
Exercise, Biomedical and Health Science, Centre for Alzheimer's Disease
RAS ID
7632
Comments

This article was originally published as: Sohrabi, H., Bates, K. A., Rodrigues, M. A., Taddei, K. , Martins, G., Laws, S., Lautenschlager, N., Dhaliwal, S., Foster, J. K., & Martins, R. N. (2009). The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eepsilon4 carriers and non-carriers. Journal of Alzheimer's disease, 17(1), 69-79. Original article available here

Abstract
Apolipoprotein E ε4 (APOE-ε4) is a major genetic risk factor for Alzheimer's disease. In this study, we addressed the question of whether possession of the APOE-ε4 allele results in adverse effects on perceived health-related quality of life (HRQL) and on symptoms of depression and anxiety in people with subjective memory complaints (SMC). 138 healthy, community-dwelling elderly volunteers, aged 52 to 85, were assessed for HRQL, depression, and anxiety. The participants were classified as i) APOE-ε4 carriers or ii) non-carriers with a) SMC or b) without memory complaints. The possible interactions of APOE genotype, gender, and SMC on HRQL, depression, and anxiety were investigated statistically. SMC was significantly associated with poorer outcomes on measures of depression, trait anxiety, and mental health. APOE-ε4 carriers did not significantly differ from non-carriers on HRQL, depression, and anxiety. However, significant interaction was found between APOE-ε4 genotype and SMC on depression. These findings are important from a health perspective and suggest that memory complaints are associated with markers of mental health and quality of life that are independent of possession of the APOE-ε4 allele, despite the importance of this polymorphism in the risk of AD and other health problems.
DOI
10.3233/JAD-2009-1018
Citation Information
Hamid Sohrabi, Kristyn Bates, Mark Rodrigues, Kevin Taddei, et al.. "The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eepsilon4 carriers and non-carriers" (2009)
Available at: http://works.bepress.com/simon_laws/7/