A novel semi-active damping device termed Variable Friction Cladding Connection (VFCC) has been previously proposed to leverage cladding systems for the mitigation of natural and man-made hazards. The VFCC is a semi-active friction damper that connects cladding elements to the structural system. The friction force is generated by sliding plates and varied using an actuator through a system of adjustable toggles. The dynamics of the device has been previously characterized in a laboratory environment. In this paper, the performance of the VFCC at mitigating non-simultaneous multi-hazard excitations that includes wind and seismic loads is investigated on a simulated benchmark building. Simulations consider the robustness with respect to some uncertainties, including the wear of the friction surfaces and sensor failure. The performance of the VFCC is compared against other connection strategies including traditional stiffness, passive viscous, and passive friction elements. Results show that the VFCC is robust and capable of outperforming passive systems for the mitigation of multiple hazards.