Skip to main content
profile image
Selected Works of Shu-Ching Chang, PhD, MS
Article
Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins.
Head & neck
  • Lauren Hum
  • Daniel Bethmann
  • Zipei Feng
  • Shu-Ching Chang, Medical Data Research Center, Providence Health & Services, Portland, OR, USA
  • Alexander Eckert
  • Carmen Ballesteros-Merino, Laboratory of Molecular and Tumor Immunology, Earle A. Chiles Research Institute, Robert W Franz Cancer Center, Providence Portland Medical Center, Portland, OR, USA.
  • Claudia Keschke
  • Matthias Kappler
  • Carlo Bifulco, Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Medical Center, Portland, OR
  • Claudia Wickenhauser
  • Barbara Seliger
  • Bernard A Fox, Chiles Research Institute Providence Portland Medical Center
  • Richard Bryan Bell, Earle A. Chiles Research Institute, Providence Cancer Institute
Link
Document Type
Article
Publication Date
10-23-2020
Disciplines
Abstract

BACKGROUND: This study aimed to analyze margin status and the impact of the immune elements on recurrence in patients with oral squamous cell carcinoma (OSCC), employing a prognostic biomarker, cumulative suppressive index (CSI), which reflects FoxP3+, PD-L1+, and CD8+ cell spatial relationships in the tumor microenvironment.

METHODS: Cox proportional hazards regression was used to evaluate the interactive effect of the margin by CSI discrepancy (high, 3-4 vs low, 0-2) on recurrence free survival (RFS) and overall survival (OS) in 119 patients with stage I to IVA OSCC.

RESULTS: In cases with negative margins, multivariable analysis showed high CSI was significantly associated with worse RFS (HR = 2.59, 95% CI [1.03, 6.49], P = .04) and OS (HR = 5.49, 95% CI [1.48, 20.35], P = .01) compared to low CSI. However, high CSI was not significantly associated with recurrence in cases with positive margins.

CONCLUSIONS: Immune architecture analysis can augment our current histopathological risk assessment of margin status.

Clinical Institute
Cancer
Department
Earle A. Chiles Research Institute
Department
Oncology
Department
Otolaryngology
Citation Information
Lauren Hum, Daniel Bethmann, Zipei Feng, Shu-Ching Chang, et al.. "Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus-negative oral squamous cell carcinomas with negative resection margins." Head & neck (2020)
Available at: http://works.bepress.com/shu-ching-chang/44/