Presentation
The Pathological Interaction Between Alzheimer’s Disease and Osteoporosis in 5xFAD Mouse Model
Student Publications & Research
Document Type
Conference Paper/Presentation
Conference
International Student Science Fair (ISSF) 2019 - March 18-22, 2019
Publication Date
3-19-2019
Advisor(s)
Ryan Ross, Ph.D.; Rush University
Keywords
- Alzheimer's Disease,
- Osteoporosis,
- Rush University,
- 5xFAD mouse model,
- bone density,
- trabecular bone,
- cortical bone
Abstract
- Alzheimer’s Disease (AD) and Osteoporosis are common degenerative diseases of aging. Previous research has found that AD and osteoporosis may overlap [4].
- Observational studies demonstrate a correlation between the osteoporosis and AD that suggest, rather than one condition causing the other, both conditions are related by a common underlying mechanism [4].
- Previous studies have investigated bone mass in mouse models that recapitulate the pathology of AD [4].
- This study focuses on the 5xFAD mouse model, another AD mouse model that exhibits a more aggressive form of AD. Thus, the 5xFAD mouse model rapidly recapitulates major features of AD amyloid pathway: rapidly accumulating Aβ42 in the brain, early amyloid deposition and gliosis, robust intraneuronal Aβ labeling, neurodegeneration and neuron loss.
- The goal of this study was to investigate the skeleton of the 5xFAD mice and compare its bone density to age-matched healthy control mice.
Creative Commons License
Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International
Citation Information
Shruti Shakthivel. "The Pathological Interaction Between Alzheimer’s Disease and Osteoporosis in 5xFAD Mouse Model" (2019) Available at: http://works.bepress.com/shruti-shakthivel/11/