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Article
Relations of Depressive Symptoms and Antidepressant Use to Body Mass Index and Selected Biomarkers for Diabetes and Cardiovascular Disease
Preventive and Behavioral Medicine Publications and Presentations
  • Yunsheng Ma, University of Massachusetts Medical School
  • Raji Balasubramanian, University of Massachusetts Amherst
  • Sherry L. Pagoto, University of Massachusetts Medical School
  • Kristin L. Schneider, University of Massachusetts Medical School
  • James R. Hebert, University of South Carolina
  • Lawrence S. Phillips, Emory University
  • Joseph S. Goveas, Medical College of Wisconsin
  • Annie L. Culver, University of Massachusetts Medical School
  • Barbara C. Olendzki, University of Massachusetts Medical School
  • James Beck, Harvard Medical School
  • Jordan W. Smoller, Massachusetts General Hospital
  • Deidre M. Sepavich, University of Massachusetts Medical School
  • Judith K. Ockene, University of Massachusetts Medical School
  • Lisa Uebelacker, Brown University
  • Martha Zorn, University of Massachussetts Amherst
  • Simin Liu, Brown University
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Date
6-13-2013
Document Type
Article
Subjects
Depression; Antidepressive Agents; Body Mass Index; Diabetes Mellitus; Cardiovascular Diseases; Biological Markers
Abstract
Objectives. We investigated whether depressive symptoms and antidepressant use are associated with biomarkers for glucose dysregulation and inflammation, body mass index (BMI), and waist circumference. Methods. Postmenopausal women were recruited into the Women's Health Initiative from 1993 to 1998, and data were collected at regular intervals through 2005. We used multiple linear regression models to examine whether depressive symptoms and antidepressant use are associated with BMI, waist circumference, and biomarkers. Results. Analysis of data from 71 809 women who completed all relevant baseline and year 3 assessments showed that both elevated depressive symptoms and antidepressant use were significantly associated with higher BMI and waist circumference. Among 1950 women, elevated depressive symptoms were significantly associated with increased insulin levels and measures of insulin resistance. Analyses of baseline data from 2242 women showed that both elevated depressive symptoms and antidepressant use were associated with higher C-reactive protein levels. Conclusions. Monitoring body habitus and other biomarkers among women with elevated depression symptoms or taking antidepressant medication may be prudent to prevent diabetes and cardiovascular disease. (Am J Public Health. Published online ahead of print June 13, 2013: e1-e10. doi:10.2105/AJPH.2013.301394).
Comments

Citation: Am J Public Health. 2013 Jun 13. Link to article on publisher's site

Related Resources
Link to Article in PubMed
PubMed ID
23763394
Citation Information
Yunsheng Ma, Raji Balasubramanian, Sherry L. Pagoto, Kristin L. Schneider, et al.. "Relations of Depressive Symptoms and Antidepressant Use to Body Mass Index and Selected Biomarkers for Diabetes and Cardiovascular Disease" (2013) ISSN: 0090-0036 (Linking)
Available at: http://works.bepress.com/sherry_pagoto/74/