Skip to main content
Article
Activating peripheral arterial disease patients to reduce cholesterol: a randomized trial
Preventive and Behavioral Medicine Publications and Presentations
  • Mary McGrae McDermott, Northwestern University
  • George W. Reed, University of Massachusetts Medical School
  • Philip Greenland, Northwestern University
  • Kathleen M. Mazor, University of Massachusetts Medical School
  • Sherry L. Pagoto, University of Massachusetts Medical School
  • Judith K. Ockene, University of Massachusetts Medical School
  • Rex Graff, Northwestern University
  • Philip A. Merriam, University of Massachusetts Medical School
  • Katherine Leung, University of Massachusetts Medical School
  • Larry Manheim, Northwestern University Feinberg School of Medicine
  • Melina R. Kibbe, Jesse Brown Veterans Administration Medical Center
  • Barbara C. Olendzki, University of Massachusetts Medical School
  • William H. Pearce, Northwestern University Feinberg School of Medicine
  • Ira S. Ockene, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavorial Medicine; Meyers Primary Care Institute; Department of Medicine, Division of Cardiovascular Medicine
Publication Date
6-25-2011
Document Type
Article
Subjects
Adult; Aged; Anticholesteremic Agents; Cholesterol, LDL; *Counseling; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Peripheral Arterial Disease; Telephone; Time Factors; Treatment Outcome
Abstract

BACKGROUND: Peripheral arterial disease patients are less likely than other high-risk patients to achieve ideal low-density lipoprotein (LDL) cholesterol levels. This randomized controlled trial assessed whether a telephone counseling intervention, designed to help peripheral arterial disease patients request more intensive cholesterol-lowering therapy from their physician, achieved lower LDL cholesterol levels than 2 control conditions.

METHODS: There were 355 peripheral arterial disease participants with baseline LDL cholesterol >/=70 mg/dL enrolled. The primary outcome was change in LDL cholesterol level at 12-month follow-up. There were 3 parallel arms: telephone counseling intervention, attention control condition, and usual care. The intervention consisted of patient-centered counseling, delivered every 6 weeks, encouraging participants to request increases in cholesterol-lowering therapy from their physician. The attention control condition consisted of telephone calls every 6 weeks providing information only. The usual care condition participated in baseline and follow-up testing.

RESULTS: At 12-month follow-up, participants in the intervention improved their LDL cholesterol level, compared with those in attention control (-18.4 mg/dL vs -6.8 mg/dL, P=.010) but not compared with those in usual care (-18.4 mg/dL vs -11.1 mg/dL, P=.208). Intervention participants were more likely to start a cholesterol-lowering medication or increase their cholesterol-lowering medication dose than those in the attention control (54% vs 18%, P=.001) and usual care (54% vs 31%, P

CONCLUSION: Telephone counseling that helped peripheral arterial disease patients request more intensive cholesterol-lowering therapy from their physician achieved greater LDL cholesterol decreases than an attention control arm that provided health information alone.

Keywords
  • UMCCTS funding
DOI of Published Version
10.1016/j.amjmed.2010.11.032
Source
Am J Med. 2011 Jun;124(6):557-65. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
21605733
Citation Information
Mary McGrae McDermott, George W. Reed, Philip Greenland, Kathleen M. Mazor, et al.. "Activating peripheral arterial disease patients to reduce cholesterol: a randomized trial" Vol. 124 Iss. 6 (2011) ISSN: 0002-9343 (Linking)
Available at: http://works.bepress.com/sherry_pagoto/58/