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Article
Elevated Depressive Symptoms, Antidepressant Use, and Diabetes in a Large Multiethnic National Sample of Postmenopausal Women
Preventive and Behavioral Medicine Publications and Presentations
  • Yunsheng Ma, University of Massachusetts Medical School
  • Raji Balasubramanian, University of Massachusetts - Amherst
  • Sherry L. Pagoto, University of Massachusetts Medical School
  • Kristin L. Schneider, University of Massachusetts Medical School
  • Annie L. Culver, Rochester Methodist Hospital, Mayo Clinic
  • Barbara C. Olendzki, University of Massachusetts Medical School
  • Lesley Tinker, Fred Hutchinson Cancer Research Center
  • Simin Liu, University of California - Los Angeles
  • Monika M. Safford, University of Alabama at Birmingham
  • Deidre M. Sepavich, University of Massachusetts Medical School
  • Milagros C. Rosal, University of Massachusetts Medical School
  • Judith K. Ockene, University of Massachusetts Medical School
  • Mercedes Carnethon, Northwestern University
  • Martha Zorn, University of Massachusetts - Amherst
  • James R. Hebert, University of South Carolina
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Date
11-1-2011
Document Type
Article
Subjects
Postmenopause; Depression; Antidepressive Agents; Diabetes Mellitus; Women's Health
Abstract
OBJECTIVE To examine elevated depressive symptoms and antidepressant use in relation to diabetes incidence in the Women’s Health Initiative. RESEARCH DESIGN AND METHODS A total of 161,808 postmenopausal women were followed for over an average of 7.6 years. Hazard ratios (HRs) estimating the effects of elevated depressive symptoms and antidepressant use on newly diagnosed incident diabetes were obtained using Cox proportional hazards models adjusted for known diabetes risk factors. RESULTS Multivariable-adjusted HRs indicated an increased risk of incident diabetes with elevated baseline depressive symptoms (HR 1.14 [95% CI 1.08–1.21]) and antidepressant use (1.20 [1.09–1.32]). These associations persisted in year 3 data, in which respective adjusted HRs were 1.23 (1.09–1.39) and 1.31 (1.14–1.50). CONCLUSIONS Postmenopausal women with elevated depressive symptoms and who use antidepressants have a greater risk of developing incident diabetes. In addition, longstanding elevated depressive symptoms and recent antidepressant medication use increase the risk of incident diabetes.
Rights and Permissions
Citation: Diabetes Care. 2011 Nov;34(11):2390-2. Epub 2011 Sep 12. DOI: 10.2337/dc11-1223. Link to article on publisher's website
Related Resources
Link to article in PubMed
PubMed ID
21911776
Citation Information
Yunsheng Ma, Raji Balasubramanian, Sherry L. Pagoto, Kristin L. Schneider, et al.. "Elevated Depressive Symptoms, Antidepressant Use, and Diabetes in a Large Multiethnic National Sample of Postmenopausal Women" Vol. 34 Iss. 11 (2011)
Available at: http://works.bepress.com/sherry_pagoto/55/