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Fluoxetine, smoking, and history of major depression: A randomized controlled trial
Preventive and Behavioral Medicine Publications and Presentations
  • Bonnie J. Spring, Northwestern University
  • Neal Doran, University of Illinois
  • Sherry L. Pagoto, University of Massachusetts Medical School
  • Dennis McChargue, University of Nebraska
  • Jessica Werth Cook, University of Illinois
  • Katherine Bailey, University of Illinois
  • John Crayton, Edward Hines Jr. Veterans Affairs Hospital
  • Donald Hedeker, University of Illinois
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Publication Date
Document Type
Adolescent; Adult; *Depressive Disorder, Major; Fluoxetine; Follow-Up Studies; Humans; Middle Aged; Questionnaires; Serotonin Uptake Inhibitors; Smoking

The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.

DOI of Published Version
J Consult Clin Psychol. 2007 Feb;75(1):85-94. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Bonnie J. Spring, Neal Doran, Sherry L. Pagoto, Dennis McChargue, et al.. "Fluoxetine, smoking, and history of major depression: A randomized controlled trial" Vol. 75 Iss. 1 (2007) ISSN: 0022-006X (Linking)
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