Fluoxetine, smoking, and history of major depression: A randomized controlled trialPreventive and Behavioral Medicine Publications and Presentations
UMMS AffiliationDepartment of Medicine, Division of Preventive and Behavioral Medicine
SubjectsAdolescent; Adult; *Depressive Disorder, Major; Fluoxetine; Follow-Up Studies; Humans; Middle Aged; Questionnaires; Serotonin Uptake Inhibitors; Smoking
AbstractThe study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.
Rights and PermissionsCitation: J Consult Clin Psychol. 2007 Feb;75(1):85-94. Link to article on publisher's site
Related ResourcesLink to Article in PubMed
Citation InformationBonnie J. Spring, Neal Doran, Sherry L. Pagoto, Dennis McChargue, et al.. "Fluoxetine, smoking, and history of major depression: A randomized controlled trial" Vol. 75 Iss. 1 (2007) ISSN: 0022-006X (Linking)
Available at: http://works.bepress.com/sherry_pagoto/25/