Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled TrialFaculty Publications, Department of Psychology
Date of this Version11-1-2007
AbstractThe study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.
Citation InformationBonnie Spring, Neal Doran, Sherry Pagoto, Dennis E. McChargue, et al.. "Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial" (2007)
Available at: http://works.bepress.com/sherry_pagoto/20/