Article
Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine
UMass Chan Medical School Faculty Publications
UMMS Affiliation
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Publication Date
2016-9-1
Document Type
Article
Disciplines
Abstract
Metastasis, drug resistance and recurrence in cancer are regulated by the tumor microenvironment. This review describes recent advances in understanding how cancer cells respond to extracellular environmental cues via integrins, how to build engineered microenvironments to study these interactions in vitro and how nanomaterials can be used to detect and target tumor microenvironments.
DOI of Published Version
10.1016/j.drudis.2016.05.011
Source
Drug Discov Today. 2016 Sep;21(9):1489-94. doi: 10.1016/j.drudis.2016.05.011. Epub 2016 May 26. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
27238384
Citation Information
Tatsuyuki Yoshii, Yingying Geng, Shelly Peyton, Arthur M. Mercurio, et al.. "Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine" Vol. 21 Iss. 9 (2016) ISSN: 1359-6446 (Linking) Available at: http://works.bepress.com/shelly_peyton/1/