Assistant Professor, Department of Chemical Engineering
Research Overview
The mission of the Peyton lab is to learn how a variety of different cell types are able to process information from biochemical and biophysical cues from the extracellular matrix (ECM), and make decisions about migration and phenotype. To do this, our lab uses both 2D and 3D biomaterial model systems, which can be engineered from the ground-up to instruct cells via both biochemical and biophysical signaling pathways. We focus on applications toward: cardiovascular disease, where tissue homeostasis is normally maintained in a mechanically dynamic ECM; stem-cell therapeutics, where rational scaffold design may be the key to directing appropriate progenitor cell migration and differentiation for tissue regeneration; and cancer, where disruptions in the local ECM microenvironment may cause drastic changes in individual cell motility and phenotype.
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The mission of the Peyton lab is to learn how a variety of different cell types are able to process information from biochemical and biophysical cues from the extracellular matrix (ECM), and make decisions about migration and phenotype. To do this, our lab uses both 2D and 3D biomaterial model systems, which can be engineered from the ground-up to instruct cells via both biochemical and biophysical signaling pathways. We focus on applications toward: cardiovascular disease, where tissue homeostasis is normally maintained in a mechanically dynamic ECM; stem-cell therapeutics, where rational scaffold design may be the key to directing appropriate progenitor cell migration and differentiation for tissue regeneration; and cancer, where disruptions in the local ECM microenvironment may cause drastic changes in individual cell motility and phenotype.
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About Shelly Peyton
Research Overview
The mission of the Peyton lab is to learn how a variety of different cell types are able to process information from biochemical and biophysical cues from the extracellular matrix (ECM), and make decisions about migration and phenotype. To do this, our lab uses both 2D and 3D biomaterial model systems, which can be engineered from the ground-up to instruct cells via both biochemical and biophysical signaling pathways. We focus on applications toward: cardiovascular disease, where tissue homeostasis is normally maintained in a mechanically dynamic ECM; stem-cell therapeutics, where rational scaffold design may be the key to directing appropriate progenitor cell migration and differentiation for tissue regeneration; and cancer, where disruptions in the local ECM microenvironment may cause drastic changes in individual cell motility and phenotype.
The mission of the Peyton lab is to learn how a variety of different cell types are able to process information from biochemical and biophysical cues from the extracellular matrix (ECM), and make decisions about migration and phenotype. To do this, our lab uses both 2D and 3D biomaterial model systems, which can be engineered from the ground-up to instruct cells via both biochemical and biophysical signaling pathways. We focus on applications toward: cardiovascular disease, where tissue homeostasis is normally maintained in a mechanically dynamic ECM; stem-cell therapeutics, where rational scaffold design may be the key to directing appropriate progenitor cell migration and differentiation for tissue regeneration; and cancer, where disruptions in the local ECM microenvironment may cause drastic changes in individual cell motility and phenotype.
| Present | Assistant Professor, Department of Chemical Engineering, University of Massachusetts Amherst | |
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Disciplines
Research Interests
Honors and Awards
- 2014 Pew Scholar, The Pew Charitable Trusts
Links
Contact Information
Chemical Engineering Department
University of Massachusetts Amherst
N531 Life Sciences Laboratories
240 Thatcher Rd
Amherst, MA 01003-9303
413-545-1133
Email: