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Cryptococcal pyelonephritis in a dog
Journal of the American Veterinary Medical Association (2003)
  • Shelley Newman
  • C E Langston
  • T Scase

A 5-year-old castrated male Golden Retriever was evaluated for polyuria, polydipsia, and progressive regurgitation thought to be a result of bacterial pyelonephritis and megaesophagus. Bacteriologic culture of urine failed to yield clinically relevant growth, and results of a urine sediment examination were normal. With time, intention tremors and progressive neurologic dysfunction were also observed. At necropsy, a diagnosis of cryptococcal disease was confirmed histologically and immunohistochemically. Findings in the dog of this report were indicative of nephrogenic diabetes insipidus with polyuria and polydipsia caused by cryptococcal pyelonephritis. Neurologic manifestations of systemic cryptococcus infection included megaesophagus, esophageal hypomotility, and regurgitation attributed to localization of cryptococcal organisms in the brain stem in the region of the dorsal motor nucleus of the vagus nerve. To the authors' knowledge, this is the first report of polyuria secondary to cryptococcal pyelonephritis.

  • Animals,
  • Central Nervous System Fungal Infections etiology,
  • Central Nervous System Fungal Infections microbiology,
  • Central Nervous System Fungal Infections veterinary,
  • Cryptococcosis complications,
  • Cryptococcosis veterinary,
  • Diagnosis,
  • Differential,
  • Dog Diseases etiology,
  • Dog Diseases microbiology,
  • Dogs,
  • Drinking,
  • Esophageal Achalasia complications,
  • Esophageal Achalasia microbiology,
  • Esophageal Achalasia veterinary,
  • Fatal Outcome,
  • Immunohistochemistry veterinary,
  • Kidney pathology,
  • Male,
  • Polyuria etiology,
  • Polyuria veterinary,
  • Pyelonephritis complications,
  • Pyelonephritis microbiology,
  • Pyelonephritis veterinary,
  • Urinalysis veterinary
Publication Date
Citation Information
Shelley Newman, C E Langston and T Scase. "Cryptococcal pyelonephritis in a dog" Journal of the American Veterinary Medical Association Vol. 222 (2003)
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