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Evaluation of surgical margins required for complete excision of cutaneous mast cell tumors in dogs
Journal of American Veterinary Medical Association (2004)
  • A M Simpson
  • J J Ludwig
  • Shelley Newman
  • P J Bergman
  • H A Hottinger
  • A K Patnaik
Abstract

OBJECTIVE: To determine whether neoplastic mast cells extended into tissue 1, 2, or 3 cm laterally or deeper than 1 fascial plane from the visible edge of cutaneous mast cell tumors (MCTs) in dogs. DESIGN: Prospective study. ANIMALS: 21 client-owned dogs with > or = 1 cutaneous MCT PROCEDURES: After preparation for surgery, each dog's skin was marked 1, 2, and 3 cm from the tumor edge at 0 degrees, 90 degrees, 180 degrees, and 270 degrees. At each 3-cm mark, deep fascia was exposed and sutured to the skin; the tumor was excised in routine fashion and fixed in formalin. Tumors were graded; margins were examined histologically for neoplastic mast cells. RESULTS: 23 cutaneous MCTs in 21 dogs were included in this study. Fifteen (65%) tumors were located on the trunk, 5 (22%) on the hind limbs, and 3 (13%) on the head and neck. There were 3 (13%) grade-I and 20 (87%) grade-II tumors. All grade-I tumors were completely excised at all margins. Seventy-five percent of the grade-II tumors were completely excised at the 1-cm margin, and 100% were completely excised at the 2-cm margin. Two grade-II MCTs located on the hind limbs of dogs were excised with a complete but close (within 1 mm) deep margin. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that a 2-cm lateral margin and a deep margin of 1 fascial plane appear to be adequate for complete excision of grade-I and -II MCTs in dogs.

Keywords
  • Animals,
  • Dog Diseases pathology,
  • Dog Diseases surgery,
  • Dogs,
  • Female,
  • Male,
  • Mast Cell Sarcoma pathology,
  • Mast Cell Sarcoma surgery,
  • Mast Cell Sarcoma veterinary,
  • Neoplasm Recurrence,
  • Local pathology,
  • Neoplasm Recurrence,
  • Local prevention & control,
  • Neoplasm Recurrence,
  • Local veterinary,
  • Neoplasm Staging veterinary,
  • Prospective Studies,
  • Skin Neoplasms pathology,
  • Skin Neoplasms surgery,
  • Skin Neoplasms veterinary
Publication Date
2004
Citation Information
A M Simpson, J J Ludwig, Shelley Newman, P J Bergman, et al.. "Evaluation of surgical margins required for complete excision of cutaneous mast cell tumors in dogs" Journal of American Veterinary Medical Association Vol. 224 (2004)
Available at: http://works.bepress.com/shelley_newman/30/