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Evaluation of two-centimeter lateral surgical margin for excision of grade 2 cutaneous mast cell tumors in dogs
Journal of the American Veterinary Medical ASsociation (2006)
  • R P Fulcher
  • L L Ludwig
  • P J Bergman
  • Shelley Newman, University of Tennessee - Knoxville
  • A M Simpson
  • A K Patnaik
Abstract

OBJECTIVE: To evaluate completeness of excision and clinical outcome in dogs with cutaneous mast cell tumors (MCTs) excised with a lateral margin of 2 cm and a deep margin of 1 fascial plane. DESIGN: Prospective study. ANIMALS: 16 client-owned dogs with 1 or more cutaneous MCTs. PROCEDURE: Excision of MCTs was performed with a 2-cm lateral margin and a deep margin of 1 fascial plane. Histologic tumor grading was performed; surgical margins were categorized as complete or incomplete. Follow-up information was obtained via repeat examination of the dogs by veterinarians or client-completed questionnaires. RESULTS: 4 grade I and 19 grade II cutaneous MCTs were evaluated. Overall, 21 (91%) MCTs were completely excised; 2 grade II tumors had foci of mast cells at the 2-cm margin. Two dogs received adjunctive treatments following surgery. Follow-up information was available for all dogs (median follow-up period, 379 days; range, 51 to 538 days); no local recurrence was detected during this time. De novo MCTs were detected in 3 of 16 dogs at 37, 54, and 154 days after surgery. Via Kaplan-Meier analysis, median survival time and disease-free interval were both > 538 days (medians not yet reached). No prognostic variables were identified. CONCLUSIONS AND CLINICAL RELEVANCE: Excision with a 2-cm lateral margin and a deep margin of 1 fascial plane may result in satisfactory excision of grades I and II MCTs in dogs, with recurrence rates similar to those reported previously. Use of these margins may minimize complications associated with larger local tumor resection.

Keywords
  • Animals,
  • Disease Free Survival,
  • Dog Diseases pathology,
  • Dog Diseases surgery,
  • Dogs,
  • Female,
  • Male,
  • Mast Cell Sarcoma pathology,
  • Mast Cell Sarcoma surgery,
  • Mast Cell Sarcoma veterinary,
  • Neoplasm Recurrence,
  • Local veterinary,
  • Neoplasm Staging veterinary,
  • Prospective Studies,
  • Skin Neoplasms pathology,
  • Skin Neoplasms surgery,
  • Skin Neoplasms veterinary,
  • Survival Analysis,
  • Treatment Outcome
Publication Date
2006
Citation Information
R P Fulcher, L L Ludwig, P J Bergman, Shelley Newman, et al.. "Evaluation of two-centimeter lateral surgical margin for excision of grade 2 cutaneous mast cell tumors in dogs" Journal of the American Veterinary Medical ASsociation Vol. 228 (2006)
Available at: http://works.bepress.com/shelley_newman/23/