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Article
Cyclooxygenase-2 expression in feline pancreatic adenocarcinomas
Journal of Veterinary Diagnostic Investigation (2006)
  • Shelley Newman, University of Tennessee - Knoxville
  • L Mrkonjich
Abstract

Cyclooxygenase-2 (COX-II) is an inducible enzyme that is responsible for the production of prostaglandin E2 (PGE2), which is often upregulated in neoplastic conditions. Expression of COX-II is documented in the majority of human pancreatic adenocarcinomas and in many epithelial neoplasms in humans and animals. The purpose of this study was to assess a series of feline pancreatic adenocarcinomas for the expression of COX-II. Eight feline pancreatic adenocarcinomas (5 poorly differentiated ductular variants and 3 well-differentiated acinar variants) were included. Immunohistochemical staining showed that COX-II was expressed in 2 (both poorly differentiated ductular variants) of the 8 neoplasms (25%). Approximately 10% of the epithelial cells from these 2 neoplasms expressed intense cytoplasmic staining. However, because feline pancreatic adenocarcinoma does not appear to consistently express COX-II, it is not a useful prognostic indicator for this group of feline neoplasms. In addition, COX-II inhibitors are not likely to be effective therapeutics for cats with this neoplasm.

Keywords
  • Adenocarcinoma enzymology,
  • Adenocarcinoma pathology,
  • Adenocarcinoma veterinary,
  • Animals,
  • Cat Diseases enzymology,
  • Cat Diseases pathology,
  • Cats,
  • Cyclooxygenase 2 biosynthesis,
  • Dinoprostone metabolism,
  • Enzyme Induction,
  • Immunohistochemistry veterinary,
  • Pancreatic Neoplasms enzymology,
  • Pancreatic Neoplasms pathology,
  • Pancreatic Neoplasms veterinary
Publication Date
2006
Citation Information
Shelley Newman and L Mrkonjich. "Cyclooxygenase-2 expression in feline pancreatic adenocarcinomas" Journal of Veterinary Diagnostic Investigation Vol. 18 Iss. 6 (2006)
Available at: http://works.bepress.com/shelley_newman/20/