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A gastric neuroendocrine carcinoma expressing somatostatin in a bearded dragon (Pogona vitticeps).
Journal of Veterinary Diagnostic Investigation (2010)
  • Jerry Lyons, University of Tennessee - Knoxville
  • Shelley Newman, University of Tennessee - Knoxville
  • Cheryl Greenacre, University of Tennessee - Knoxville
  • John Duncan, University of Tennessee - Knoxville
Abstract

A metastatic gastric neuroendocrine carcinoma in a 2.5-year-old inland bearded dragon (Pogona vitticeps) with a chronic history of anorexia, weight loss, depression, and acute melena is described. Histologic examination of the gastric mass revealed a densely cellular tumor arranged in nests and occasional rosettes of hyperchromatic cells with oval to spindle-shaped nuclei and minimal cytoplasm; the tumor was supported by a moderate fibrovascular stroma. Similar cells invaded through the gastric mucosa, and there were multiple hepatic metastases. The neoplastic cells were weakly immunopositive for neuron-specific enolase and moderately positive for somatostatin but were negative for chromogranin AB and gastrin. Ultrastructural studies revealed scattered neurosecretory granules in the neoplastic cells, confirming the diagnosis of a neuroendocrine carcinoma.

Keywords
  • Gastric,
  • inland bearded dragon,
  • lizards,
  • neuroendocrine carcinoma,
  • Pogona viticeps,
  • somatostatin
Publication Date
March, 2010
Citation Information
Jerry Lyons, Shelley Newman, Cheryl Greenacre and John Duncan. "A gastric neuroendocrine carcinoma expressing somatostatin in a bearded dragon (Pogona vitticeps)." Journal of Veterinary Diagnostic Investigation Vol. 22 Iss. 2 (2010)
Available at: http://works.bepress.com/shelley_newman/2/