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Article
Effect of Low Molecular Weight Heparin on Fracture Healing in a Stabilized Rat Femur Fracture Model
Journal of Orthopaedic Research
  • David J. Hak, University of California - Davis
  • Rena L. Stewart, Indiana University School of Medicin
  • Scott J. Hazelwood, University of California - Davis
Publication Date
4-1-2006
Abstract

The purpose of this studywas to evaluate the effect of low molecular weight heparin (LMWH) on fracture healing in a standard stabilized rat femur fracture model. A closed, mid-diaphyseal transverse fracture was created in the right femur of Long-Evans rats after insertion of a 0.8-mm K-wire into the medullarycanal. Animals were randomized to receive either LMWH (70 units/kg dalteparin) oraninjection of normal saline daily for 2 weeks. Animals were sacrificed at 2, 3, and 6 weeks. Fracture healing was assessedbyradiographs, histology, and mechanical testing. There were no significant differences between the control and LMWH groups in the percentage of animalswith radiographic bridging callus at each time point. Histologicappearance of fracture healing was similar between the control and LMWH groups. There were no significant differences in the normalized mechanical properties of the control and LMWH groups at 2 and 3 weeks. At 6 weeks, the percent torque of the LMWH group was significantly greater thanthe control group (p = 0.00 72), however, there was no significant difference in the stiffness and energy absorption. Dalteparin, at the dosage used in this study, did not impair fracture healing in this standard stabilized rat femur fracture model.

Publisher statement
This is the pre-peer reviewed version of the following article: Effect of Low Molecular Weight Heparin on Fracture Healing in a Stabilized Rat Femur Fracture Model, David J. Hak, Rena L. Stewart, Scott J. Hazelwood, Journal of Orthopaedic Research, 24:4.
Citation Information
David J. Hak, Rena L. Stewart and Scott J. Hazelwood. "Effect of Low Molecular Weight Heparin on Fracture Healing in a Stabilized Rat Femur Fracture Model" Journal of Orthopaedic Research Vol. 24 Iss. 4 (2006) p. 645 - 652
Available at: http://works.bepress.com/shazelwo/24/