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Article
Survival Following Tumor Recurrence in Children With Medulloblastoma
Journal of Pediatric Hematology/Oncology
  • Donna L Johnston
  • Daniel Keene
  • Douglas Strother
  • Maria Taneva
  • Lucie Lafay-Cousin
  • Chris Fryer
  • Katrin Scheinemann
  • Anne-Sophie Carret
  • Adam Fleming
  • Samina Afzal
  • Beverly Wilson
  • Lynette Bowes
  • Shayna Zelcer, London Health Science Centre
  • Chris Mpofu
  • Mariana Silva
  • Valerie Larouche
  • Josee Brossard
  • Eric Bouffet
Document Type
Article
Publication Date
4-1-2018
URL with Digital Object Identifier
https://doi.org/10.1097/MPH.0000000000001095
Disciplines
Abstract

Medulloblastoma is the most common malignant brain tumor in children. Published survival rates for this tumor are ∼70%; however, there is limited published information on outcome after disease recurrence. This was an observational study which included all persons under the age of 18 years diagnosed with medulloblastoma from 1990 to 2009 inclusive in Canada. Data collected included date of diagnosis, age at diagnosis, sex, stage, pathology, treatment, recurrence, and current status. Survival rates were determined. In total, 550 cases were ascertained meeting the study criteria. The overall survival rate at 1 year was 83.6%±1.7%, at 3 years 77.2%±1.9%, and at 5 years 72.5%±20%. The progression-free survival rates were 78%±1.9%, 70%±2.1%, and 69±2.1% at 1, 3, and 5 years from initial diagnosis. In total, 173 (31.2%) were reported to have had tumor recurrence and 23 (11.4%) of them were alive at the time of survey with an overall survival rate at 1 year of 38.3%±4%, at 2 years of 16.9%±3.3%, and at 5 years of 12.4%±2.8%. Our data confirm that children with recurrent medulloblastoma have a poor prognosis, supporting the need for novel treatment approaches for this group.

Notes

Article available at Journal of Pediatric Hematology/Oncology, Vol. 40(3).

https://doi.org/10.1097/MPH.0000000000001095

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

Citation Information
Donna L Johnston, Daniel Keene, Douglas Strother, Maria Taneva, et al.. "Survival Following Tumor Recurrence in Children With Medulloblastoma" Journal of Pediatric Hematology/Oncology Vol. 40 Iss. 3 (2018) p. 159 - 159
Available at: http://works.bepress.com/shayna-zelcer/3/