Regardless of theoretical orientation or work setting, professional counselors should have a thorough understanding of the American Psychiatric Association’s (APA) fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). This article includes an overview of the most recent revision process and identification of key structural and philosophical changes in the DSM-5. The authors conclude with a summary of practice implications for counselors, including specific guidance for recording diagnoses, using diagnostic specifiers and incorporating emerging assessment measures.