This study examined the difference between the relationship of socio-demographic variables as well as the intersection between race/ethnicity and gender on nine indicators of social distance from people with mental health conditions (MHC). Secondary analysis of a randomized telephone survey drawn from the Missouri Institute of Mental Health and the Missouri Mental Health Foundation in the spring of 2013 was conducted. The sample included 2,244 Midwestern respondents. Multivariate logistic regressions were utilized. The sample was mostly White (91.7%) and female (59.8%), with a mean age of 57.1 years. Being female, 65+ years of age, and having a higher annual income ($50,000+) was associated with a lower preference for social interactions with individuals experiencing MHC. Black males, however, had an increased willingness to interact with this population. Findings suggest that it may be beneficial for anti-stigma programs to target populations that seem to be consistently less willing to interact with individuals experiencing MHC (e.g., individuals who are older or who have a higher annual income). Additional research is needed to explore why Black men may be more willing to interact with people with MHC.