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Article
Synthesis of Pyrazoles by a One-Pot Tandem Cyclization-Dehydrogenation Approach on Pd/C/K-10 Catalyst
Synlett (2007)
  • Shainaz M. Landge, University of Massachusetts
  • Allison Schmidt, University of Massachusetts, Boston
  • Verona M. Outerbridge, University of Massachusetts, Boston
  • Béla Török, University of Massachusetts Boston
Abstract
A novel one-pot synthesis of substituted pyrazoles from chalcones and hydrazines via a tandem cyclization-dehydro­genation approach is described. This process is based on the use of a bifunctional noble-metal/solid-acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation under solvent-free conditions. The cyclization of chalcones with hydrazines readily takes place on the strong solid acid while the presence of the metal ensures the ­formation of the aromatic product through dehydrogenation. The ­reactions are complete in 30 minutes providing good yields and high selectivities.
Keywords
  • Chalcones,
  • Hydrazines,
  • Bifunctional catalysis,
  • Microwave heating,
  • Pyrazoles
Disciplines
Publication Date
March, 2007
DOI
10.1055/s-2007-982545
Publisher Statement
Authors can archive a copy of the article on their personal webpage. Article obtained from Synlett
Citation Information
Shainaz M. Landge, Allison Schmidt, Verona M. Outerbridge and Béla Török. "Synthesis of Pyrazoles by a One-Pot Tandem Cyclization-Dehydrogenation Approach on Pd/C/K-10 Catalyst" Synlett Vol. 10 (2007) p. 1600 - 1604
Available at: http://works.bepress.com/shainaz_landge/44/