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Microwave-Assisted Solid Acid-Catalyzed One- Pot Synthesis of Isobenzofuran-1(3H)-one
Tetrahedron Letters (2008)
  • Shainaz M. Landge, Georgia Southern University
  • Martin Berryman, University of Massachusetts
  • Béla Török, University of Massachusetts
A new, solid acid-catalyzed microwave-assisted environmentally benign synthesis of isobenzofuran-1(3H)-ones is described. Montmorillonite K-10 appeared to be an excellent catalyst for the condensation and successive lactonization reactions. Reaction of phthalaldehydic acid (2-carboxybenzaldehyde) with methylaryl and cyclic ketones was initiated by microwave irradiation and occurred in one step. The reactions were complete in 10–30 minutes providing excellent yields (90–98%).
  • Condensation,
  • Isobenzofuran-1(3H)-one,
  • Microwave irradiation,
  • Montmorillonite K-10
Publication Date
Citation Information
Shainaz M. Landge, Martin Berryman, and Béla Török. "Microwave-Assisted Solid Acid-Catalyzed One- Pot Synthesis of Isobenzofuran-1(3H)-one" Tetrahedron Letters 49.29-30 (2008): 4505-4508.