"Multicomponent Domino Cyclization- Oxidative Aromatization on a Bifunctional Pd/C/K -10 Catalyst: An Environmentally Benign Approach toward the Synthesis of Pyridines" by Shainaz M. Landge

Article

Multicomponent Domino Cyclization- Oxidative Aromatization on a Bifunctional Pd/C/K -10 Catalyst: An Environmentally Benign Approach toward the Synthesis of Pyridines

Synthesis (2008)

Shainaz M. Landge, Georgia Southern University
Omar De Paolis, University of Massachusetts
Jonathan Baffoe, University of Massachusetts
Béla Török, University of Massachusetts

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Abstract

A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization (dehydrogenation) approach is described. The process is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation. The cyclization readily takes place on the strong solid acid while palladium dehydrogenates the dihydropyridine intermediates to the desired products.

Keywords

Pd/C/K-10 montmorillonite,
solid acid,
microwave irradiation,
bifunctional catalysis,
green chemistry,
pyridines

Disciplines

Chemistry

Publication Date

2008

Citation Information

Shainaz M. Landge, Omar De Paolis, Jonathan Baffoe, and Béla Török. "Multicomponent Domino Cyclization- Oxidative Aromatization on a Bifunctional Pd/C/K -10 Catalyst: An Environmentally Benign Approach toward the Synthesis of Pyridines" Synthesis 21 (2008): 3423-3428.
doi:10.1055/s-0028-1083177