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Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones
Synthesis (2009)
  • Verona M. Outerbridge, University of Massachusetts
  • Shainaz M. Landge, Georgia Southern University
  • Hiroko Tamaki, University of Massachusetts
  • Béla Török, University of Massachusetts
A one-pot, solid-acid-catalyzed, microwave-assisted synthesis of phthalazinones is described. The commercially available montmorillonite K-10 effectively catalyzed the condensation and substitution reactions. The approach was based on the direct cyclization of phthalaldehydic acid and opianic acid with substituted hydrazines. The reactions provided excellent yields and high selectivities in very short time (5-35 minutes).
  • Phthalazinones,
  • phthalaldehydic acid,
  • opianic acid,
  • hydrazines,
  • montmorillonite K-10,
  • microwave heating
Publication Date
Citation Information
Verona M. Outerbridge, Shainaz M. Landge, Hiroko Tamaki, and Béla Török. "Microwave-Promoted Solid-Acid Catalyzed One-Pot Synthesis of Phthalazinones" Synthesis 11 (2009): 1801-1806.