Highly Enantioselective Organocatalytic Addition of Ethyl Trifluoropyruvate to Ketones with SubZero Temperature Microwave ActivationCatalysis Letters (2009)
AbstractAn enantioselective organocatalytic microwave-assisted method for the addition of ethyl trifluoropyruvate to ketones to synthesize highly enantiomerically enriched organofluorine synthons is described. Besides the high yields, diastereo- and enantioselectivities, the most important observation is that the use of microwave irradiation at subzero temperatures proved to be beneficial. The results indicate that subzero temperature microwave chemistry is a potentially intriguing tool for asymmetric synthesis.
- Microwave irradiation,
- Asymmetric synthesis,
- Subzero temperature,
Citation InformationShainaz M. Landge and Béla Török. "Highly Enantioselective Organocatalytic Addition of Ethyl Trifluoropyruvate to Ketones with SubZero Temperature Microwave Activation" Catalysis Letters 131.3-4 (2009): 432-439.