Article
Highly Enantioselective Organocatalytic Addition of Ethyl Trifluoropyruvate to Ketones with SubZero Temperature Microwave Activation
Catalysis Letters
(2009)
Abstract
An enantioselective organocatalytic microwave-assisted method for the addition of ethyl trifluoropyruvate to ketones to synthesize highly enantiomerically enriched organofluorine synthons is described. Besides the high yields, diastereo- and enantioselectivities, the most important observation is that the use of microwave irradiation at subzero temperatures proved to be beneficial. The results indicate that subzero temperature microwave chemistry is a potentially intriguing tool for asymmetric synthesis.
Keywords
- Microwave irradiation,
- Asymmetric synthesis,
- Organofluorine,
- Subzero temperature,
- Organocatalysis
Disciplines
Publication Date
2009
Citation Information
Shainaz M. Landge and Béla Török. "Highly Enantioselective Organocatalytic Addition of Ethyl Trifluoropyruvate to Ketones with SubZero Temperature Microwave Activation" Catalysis Letters 131.3-4 (2009): 432-439.doi:10.1007/s10562-009-0102-0