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Article
Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis
Journal of Microbiology, Immunology, and Infection
  • Masood K I, Aga Khan University
  • Shahid Pervez, Section of Histopathology, Dept of Pathology & Laboratory Medicine, Aga Khan University Hospital, Karachi
  • Rottenberg M E, Karolinska Institutet
  • Umar B, Aga Khan University
  • Hasan Z, Aga Khan University
Publication Date
9-1-2015
Document Type
Article
Disciplines
Abstract
We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.
Citation Information
Masood K I, Shahid Pervez, Rottenberg M E, Umar B, et al.. "Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis" Journal of Microbiology, Immunology, and Infection (2015)
Available at: http://works.bepress.com/shahid_pervez/134/