"Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis" by Masood K I

Article

Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis

Journal of Microbiology, Immunology, and Infection

Masood K I, Aga Khan University
Shahid Pervez, Section of Histopathology, Dept of Pathology & Laboratory Medicine, Aga Khan University Hospital, Karachi
Rottenberg M E, Karolinska Institutet
Umar B, Aga Khan University
Hasan Z, Aga Khan University

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Publication Date

9-1-2015

Document Type

Article

Disciplines

Abstract

We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.

Citation Information

Masood K I, Shahid Pervez, Rottenberg M E, Umar B, et al.. "Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis" Journal of Microbiology, Immunology, and Infection (2015)
Available at: http://works.bepress.com/shahid_pervez/134/