Article
Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis
Journal of Microbiology, Immunology, and Infection
Publication Date
9-1-2015
Document Type
Article
Disciplines
- Cells,
- Immunopathology and
- Oncology
Abstract
We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.
Citation Information
Masood K I, Shahid Pervez, Rottenberg M E, Umar B, et al.. "Suppressor of Cytokine signaling-1 and Chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous Necrosis in Granulomas from patients with Tuberculous Lymphadenitis" Journal of Microbiology, Immunology, and Infection (2015) Available at: http://works.bepress.com/shahid_pervez/134/