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Furazolidone, Co-amoxiclav, Colloidal Bismuth Subcitrate, and Esomeprazole for patients who failed to eradicate Helicobacter pylori with triple therapy
Digestive Diseases and Sciences
  • Z Abbas, Aga Khan University
  • Javed Yakoob, Aga Khan University
  • Shahab Abid, Aga Khan University
  • Wasim Jafri, Aga Khan University
  • Muhammad Islam, Aga Khan University
  • Zahid Azam, Aga Khan University
  • Imran Hilal, Aga Khan University
Publication Date
9-1-2009
Document Type
Article
Abstract
There is increasing evidence of Helicobacter pylori (H. pylori) resistance to the classical triple therapy consisting of a proton-pump inhibitor and clarithromycin with either amoxicillin or metronidazole. This study is aimed at establishing the efficacy and safety of a 14-day regimen to eradicate H. pylori in patients who have failed with the classical triple therapy given for 14 days. One hundred seventy-six patients diagnosed to have H. pylori infection were given triple therapy for 14 days. Fifty-two patients who failed to respond as evident from positive 14C-urea breath test (UBT) done 4–6 weeks after the completion of triple therapy were offered a combination regimen comprised of furazolidone 200 mg b.i.d, co-amoxiclav 1 g b.i.d., colloidal bismuth subcitrate 240 mg b.i.d., and esomeprazole 40 mg b.i.d. for 14 days. The mean age of these patients was 41 ± 13 years (range 20–67). Thirty-four were males. To document eradication of H. pylori, UBT was repeated 4 weeks after the completion of treatment. On an intention-to-treat analysis, the eradication rate was 81% (42 out of 52) whereas on per-protocol basis, the eradication rate was 82.4% (42 out of 51). In conclusion, this new regimen represents a suitable second-line therapy.
Citation Information
Z Abbas, Javed Yakoob, Shahab Abid, Wasim Jafri, et al.. "Furazolidone, Co-amoxiclav, Colloidal Bismuth Subcitrate, and Esomeprazole for patients who failed to eradicate Helicobacter pylori with triple therapy" Digestive Diseases and Sciences Vol. 54 Iss. 9 (2009) p. 1953 - 1957
Available at: http://works.bepress.com/shahab_abid/8/