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Article
Magnetic resonance microscopy for monitoring osteogenesis in tissue-engineered construct in vitro.
Physics in Medicine and Biology
  • Huihui Xu, University of the Pacific
  • Shadi F. Othman, University of the Pacific
  • Liu Hong, University of Illinois
  • Ioana A. Peptan, University of Illinois
  • Richard L. Magin, University of Illinois
Document Type
Article
DOI
10.1088/0031-9155/51/3/016
Publication Date
2-7-2006
Abstract
Magnetic resonance microscopy (MRM) is used to monitor osteogenesis in tissue-engineered constructs. Measurements of the developing tissue's MR relaxation times (T(1) and T(2)), apparent diffusion coefficient (ADC) and elastic shear modulus were conducted over a 4-week growth period using an 11.74 T Bruker spectrometer with an imaging probe adapted for MR elastography (MRE). Both the relaxation times and the ADC show a statistically significant decrease after only one week of tissue development while the tissue stiffness increases progressively during the first two weeks of in vitro growth. The measured MR parameters are correlated with histologically monitored osteogenic tissue development. This study shows that MRM can provide quantitative data with which to characterize the growth and development of tissue-engineered bone.
Citation Information
Huihui Xu, Shadi F. Othman, Liu Hong, Ioana A. Peptan, et al.. "Magnetic resonance microscopy for monitoring osteogenesis in tissue-engineered construct in vitro." Physics in Medicine and Biology Vol. 51 Iss. 3 (2006) p. 719 - 732 ISSN: 0031-9155
Available at: http://works.bepress.com/shadi-othman/14/