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Article
Determination of withdrawal time for oxytetracycline in different types of goats for milk consumption
Journal of Dairy Science
  • Rahmat Attaie, Prairie View A and M University
  • Mohammed Bsharat, Prairie View A and M University
  • Adela Mora-Gutierrez, Prairie View A and M University
  • Sela Woldesenbet, Prairie View A and M University
Document Type
Article
Abstract

Antibiotics are widely used in animal husbandry and the presence of antibiotics in milk is a health hazard. The objective of this study was to determine residual amounts of oxytetracycline in fresh, aged, and pasteurized milk of 3 breeds of goats using HPLC analysis. It was also essential to determine the safe withdrawal period of oxytetracycline in lactating goats. The quantitative results obtained using the HPLC system were compared with the tolerance limit of oxytetracycline in milk in the United States. Fifteen milking does, 5 Nubians, 5 Alpines, and 5 LaManchas were randomly selected from the milking herd at the International Goat Research Center at Prairie View A&M University. A simple sample preparation and isocratic HPLC method using ultraviolet detection was used for analysis of milk samples. The HPLC results indicated that the withdrawal period of oxytetracycline in treated Alpine does was 82. h (7 milking), whereas for Nubian does the period was 58. h (5 milking), and for LaManchas the period was 72. h (6 milking) after drug administration. The overall withdrawal period for all the treated goats of 3 breeds was 72. h. Although these results indicated that the depletion rate of this antibiotic was faster in goats than the reported data for cows, the 96-h withdrawal period that is currently used for lactating cows is still necessary for these 3 breeds of goats. Additionally, our results indicated that oxytetracycline is not stable in goat milk at refrigeration temperature or during pasteurization and will decrease significantly.

DOI
10.3168/jds.2014-8616
Publication Date
7-1-2015
Citation Information
Rahmat Attaie, Mohammed Bsharat, Adela Mora-Gutierrez and Sela Woldesenbet. "Determination of withdrawal time for oxytetracycline in different types of goats for milk consumption" Journal of Dairy Science Vol. 98 Iss. 7 (2015) p. 4370 - 4376 ISSN: 00220302
Available at: http://works.bepress.com/selamawit-woldesenbet/33/