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Article
Parallel strategies for the synthesis of annulated pyrido[3,4-b]indoles via Rh(I)- and Pd(0)-catalyzed cyclotrimerization
Tetrahedron Letters
(2018)
Abstract
Two different pathways for the synthesis of annulated pyrido[3,4-b]indoles are reported using metal-catalyzed cyclotrimerization reactions. A stepwise process using Rh(I)-catalysis in the final step of the synthesis and a multicomponent, tandem catalytic approach using Pd(0)-catalysis both lead to complex nitrogen-containing heterocycles in good yields. Substituent effects are investigated for both pathways, demonstrating that the Pd(0)-catalyzed approach is more sensitive to electron-withdrawing groups.
Disciplines
Publication Date
December, 2018
Citation Information
Bianca M Saliba, Satyam Khanal, Michael A O’Donnell, Kathryn E Queenan, et al.. "Parallel strategies for the synthesis of annulated pyrido[3,4-b]indoles via Rh(I)- and Pd(0)-catalyzed cyclotrimerization" Tetrahedron Letters Vol. 59 Iss. 49 (2018) p. 4311 - 4314 ISSN: 0040-4039 Available at: http://works.bepress.com/seann_mulcahy/16/