Article
DNA-binding studies of the natural β-carboline eudistomin U
Bioorganic and Medicinal Chemistry Letters,
(2016)
Abstract
Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV–Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class.
Keywords
- β-Carboline,
- DNA,
- Eudistomin U,
- UV–Vis,
- Thermal denaturation,
- Circular dichroism,
- Differential scanning calorimetry
Disciplines
Publication Date
October, 2016
DOI
https://doi.org/10.1016/j.bmcl.2016.08.047
Citation Information
Jennifer M Giulietti, Patrick M. Tate, Ang Cai, Bongsup Cho, et al.. "DNA-binding studies of the natural β-carboline eudistomin U" Bioorganic and Medicinal Chemistry Letters, Vol. 29 Iss. 19 (2016) p. 4705 - 4708 ISSN: 0960-894X Available at: http://works.bepress.com/seann_mulcahy/13/