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Efficient synthesis of eudistomin U and evaluation of its cytotoxicity
Bioorganic & Medicinal Chemistry Letters (2014)
  • Seann P. Mulcahy, Providence College
  • Chad M. Roggero
  • Jennifer M. Giulietti
Abstract

Eudistomin U is a member of a subclass of naturally occurring indole alkaloids known as β-carbolines. These molecules are reported to have diverse biological activity and high binding affinity to DNA, which make them attractive targets for total synthesis. We describe an efficient, five-step synthesis of eudistomin U by employing two key reactions: a Bischler–Napieralski cyclization and a Suzuki cross coupling. We also describe the cytotoxicity of eudistomin U against various cancer cell lines and human pathogens, in which we observed potent antibacterial activity against Gram-positive bacteria.

Disciplines
Publication Date
August, 2014
Citation Information
Seann P. Mulcahy, Chad M. Roggero and Jennifer M. Giulietti. "Efficient synthesis of eudistomin U and evaluation of its cytotoxicity" Bioorganic & Medicinal Chemistry Letters Vol. 24 Iss. 15 (2014)
Available at: http://works.bepress.com/seann_mulcahy/11/