Zebra and quagga mussels (Dreissena polymorpha and D. rostriformis bugensis, respectively) were not detected by Oregon Department of Fish and Wildlife (ODFW) and Portland State University (PSU) during their early detection sampling in Oregon water bodies during 2014. Six high-risk Oregon water bodies were sampled for planktonic larvae and adult mussels during the August to September period. A total of 37 plankton samples were collected and over 520,000 liters of reservoir/lake water were filtered through 64-μm mesh nets during plankton sample collection. The greatest sampling effort occurred in Emigrant Lake, Lake Billy Chinook, and Prineville Reservoir but sampling also occurred in Howard Prairie Lake, Upper Klamath Lake, and Applegate Reservoir. Non-native invertebrates and macrophytes were opportunistically collected during Dreissena sampling in 2014. Corbicula fluminea (Asian clam) adults were collected in Upper Klamath Lake. Potamopyrgus antipodarum (New Zealand mud snails) were collected in Lake Billy Chinook. Potamogeton crispus (curly leaf pondweed) was collected in Emigrant Lake, Howard Prairie Lake, Lake Billy Chinook, and Upper Klamath Lake. To the authors’ knowledge, the C. fluminea in Upper Klamath Lake represents the first reported detection for these species in this location.