Article
A clinico-pathological study of 70 cases of pemphigus
Indian Journal of Dermatology, Venereology and Leprology
(1999)
Abstract
A clinicopalhological study of 70 cases of pemphigus observed over a span of four and a half years from January 1992 to June 1996 at the Sir J.J. Group of Hospitals and Grant Medical College, Mumbai is reported. Pemphigus vulgaris constituted the single largest group of 43 cases, followed by pemphigus foliaceus (25 cases) and pemphigus vegetans (2 cases). Majority of the cases were seen in the age group of 21-60 years, with a slight male predominance. The youngest patient was 14 years while the eldest was aged 75 years. Mucosal involvement was seen in 31 cases of pemphigus vulgaris, as opposed to only 5 cases of pemphigus foliaceus. Flaccid bullae were present in 100% cases. Pruritus was complained of in 14 cases, though it was more common in pemphigus vegetans and vulgaris. Salient histopathological features of pemphigus vulgaris observed were (I) intraepidermal suprabasal blisters (35 cases), (2) presence of acantholytic cells (40 cases), (3) "Row of tombstone appearance" (I8 cases) and (4) acantholysis involving follicular sheath (20 cases). Main histopathological features of pemphigus foliaceus were (1) subcorneal blister (15 case), (2) acantholysis (24 cases) and (3) bulla cavity containing inflammatory infiltrate (12 cases). Both cases of pemphigus vegetans showed hyperkeratosis, papillomatosis and irregular acanthosis with intra-epidermal eosinophilic abscesses besides suprabasal lacunae.
Keywords
- Pemphigus vulgaris,
- Pemphigus foliaceus,
- Pemphigus vegetans
Disciplines
Publication Date
1999
DOI
http://www.ijdvl.com/article.asp?issn=0378-6323;year=1999;volume=65;issue=4;spage=168;epage=171;aulast=Arya
Citation Information
Savita Arya, A G Valand and K Krishna. "A clinico-pathological study of 70 cases of pemphigus" Indian Journal of Dermatology, Venereology and Leprology Vol. 65 Iss. 4 (1999) p. 168 - 171 Available at: http://works.bepress.com/savita-arya/8/