During routine dissection of 10 cadavers that originated from the Body Donor Program at Philadelphia College of Osteopathic Medicine South Georgia, an 82-year-old female with a Baker's cyst anomaly located medially in the right popliteal fossa was encountered. The Baker's cyst contained synovial fluid in a thick bursal covering. This finding is suggestive of pathology in the knee joint, such as arthritis or a tear in cartilage or ligaments. This case study analyzes the Baker's cyst found during dissection and its clinical significance.