Myxoidliposarcomas ofthe head and neck aremostly metastaticin nature, with the primarylesion usually in lower extremities or retroperitoneum. Primary mediastinal liposarcomas are even rare Although there have been previous cases reporting their incidence, there is no evidence of any case comprising of both the neck and the mediastinal region yet. We here present a case of a 43 year old male with a primary liposarcoma of the myxoid subtype originating in the anterior mediastinumThis is the first time such a case haspres ented in literature. The patient presented with a right sided neck swelling associated with pain and shortness of breath upon lying down.CT neck revealed an enhancing mass extending from right cervical regionto axilla and enca sing the subclavian artery and involving a portion of the right lung. The patient underwent wide local excision of the mass along with chemo radiotherapy to prevent recurrence