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Triticum mosaic poacevirus enlists P1 rather than HC-Pro to suppress RNA silencing-mediated host defense
Virology Papers
  • Satyanarayana Tatineni, University of Nebraska-Lincoln
  • Feng Qu, Ohio State University
  • Ruhui Li, National Germplasm Resources Laboratory
  • Thomas Jack Morris, University of Nebraska-Lincoln
  • Roy French, University of Nebraska-Lincoln
Date of this Version
1-1-2012
Citation

Virology 433(2012)104–115; http://dx.doi.org/10.1016/j.virol.2012.07.016

Abstract
Triticum mosaic virus (TriMV) is the type species of the newly established Poacevirus genus in the family Potyviridae. In this study, we demonstrate that in contrast to the helper component- proteinase (HC-Pro) of Potyvirus species, the P1 proteins of TriMV and Sugarcane steak mosaic poacevirus function in suppression of RNA silencing (SRS). TriMV P1 effectively suppressed silencing induced by single- or double-stranded RNAs (ss/ds RNAs), and disrupted the systemic spread of silencing signals at a step after silencing signal production. Interestingly, contrary to enhanced SRS activity of potyviral HC-Pro by co-expression with P1, the presence of TriMV HC-Pro reduced SRS activity of TriMV P1. Furthermore, TriMV P1 suppressed systemic silencing triggered by dsRNA more efficiently than the HC-Proof Turnip mosaic potyvirus. Furthermore, TriMV P1 enhanced the pathogenicity of a heterologous virus. Our results established poaceviral P1 as a potent RNA silencing suppressor that probably employs a novel mechanism to suppress RNA silencing-based antiviral defense.
Citation Information
Satyanarayana Tatineni, Feng Qu, Ruhui Li, Thomas Jack Morris, et al.. "Triticum mosaic poacevirus enlists P1 rather than HC-Pro to suppress RNA silencing-mediated host defense" (2012)
Available at: http://works.bepress.com/satyanarayana_tatineni/4/