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Article
Nitro-Oxidative Stress Biomarkers in Active and Inactive Men
International Journal of Sports Medicine (2012)
  • L. Bjork
  • N. T. Jenkins, University of Maryland
  • Sarah Witkowski, University of Massachusetts - Amherst
  • J. M. Hagberg, University of Maryland
Abstract

Oxidative stress markers are novel factors shown to be related to cardiovascular (CVD) risk. We examined the effects of long-term exercise, age, and their interaction on plasma oxidized LDL (ox-LDL), nitrotyrosine, and myeloperoxidase (MPO) levels, all biomarkers of oxidative stress, and determined their association with plasma nitric oxide (NOx) levels as an index of NO bioavailability. Older (62±2 yr) active men (n=12) who had exercised for >30 years and young (25±4 yr) active men (n=7) who had exercised for >3 years were age- and BMI-matched to older (n=11) and young (n=8) inactive men. Young subjects had lower plasma nitrotyrosine levels than older subjects (P=0.047). Young inactive subjects had higher ox-LDL levels than either the young active (P=0.042) or the older active (P=0.041) subjects. In addition, plasma oxidative stress levels, particularly ox-LDL, were correlated with various conventional plasma lipoprotein-lipid levels, and in older subjects were associated with Framingham risk score (r=0.49, P=0.015). We found no relationships between plasma oxidative stress markers and NOx levels. The findings suggest that a sedentary lifestyle may be associated with higher ox-LDL levels and that the levels of oxidative stress markers are related to levels of other conventional CVD risk factors and overall CVD risk.

Disciplines
Publication Date
2012
Publisher Statement
The published version is located at https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1301891
Citation Information
L. Bjork, N. T. Jenkins, Sarah Witkowski and J. M. Hagberg. "Nitro-Oxidative Stress Biomarkers in Active and Inactive Men" International Journal of Sports Medicine Vol. 33 Iss. 4 (2012)
Available at: http://works.bepress.com/sarah_witkowski/7/