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Selected Works of Sarah Sass
Article
Depression and anxious apprehension distinguish frontocingulate cortical activity during top-down attentional control.
Journal of Abnormal Psychology (2011)
  • Rebecca Levin Silton, University of Illinois at Urbana–Champaign
  • Wendy Heller, University of Illinois at Urbana–Champaign
  • Anna S. Engels, University of Illinois at Urbana–Champaign
  • David N. Towers, University of Illinois at Urbana–Champaign
  • Jeffrey M. Spielberg, University of Illinois at Urbana–Champaign
  • J. Christopher Edgar, University of Illinois at Urbana–Champaign
  • Sarah M. Sass, University of Illinois at Urbana–Champaign
  • Jennifer L. Stewart, University of Illinois at Urbana–Champaign
  • Bradley P. Sutton, Illinois College
  • Bradley P. Sutton, University of Illinois at Urbana–Champaign
  • Marie T. Banich, University of Colorado Boulder
  • Gregory A. Miller, University of Illinois at Urbana–Champaign
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Abstract
A network consisting of left dorsolateral prefrontal cortex (LDLPFC) and dorsal anterior cingulate cortex (dACC) has been implicated in top-down attentional control. Few studies have systematically investigated how this network is altered in psychopathology, despite evidence that depression and anxiety are associated with attentional control impairments. Functional MRI and dense-array event-related brain potential (ERP) data were collected in separate sessions from 100 participants during a color–word Stroop task. Functional MRI results guided ERP source modeling to characterize the time course of activity in LDLPFC (300–440 ms) and dACC (520–680 ms). At low levels of depression, LDLPFC activity was indirectly related to Stroop interference and only via dACC activity. In contrast, at high levels of depression, dACC did not play an intervening role, and increased LDLPFC activity was directly related to decreased Stroop interference. Specific to high levels of anxious apprehension, higher dACC activity was related to more Stroop interference. Results indicate that depression and anxious apprehension modulate temporally and functionally distinct aspects of the frontocingulate network involved in top-down attention control. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Keywords
  • Depression,
  • Mental Health,
  • Frontocingulate cortical activity,
  • top-down attention control
Disciplines
Publication Date
May 1, 2011
DOI
10.1037/A0023204
Citation Information
Rebecca Levin Silton, Wendy Heller, Anna S. Engels, David N. Towers, et al.. "Depression and anxious apprehension distinguish frontocingulate cortical activity during top-down attentional control." Journal of Abnormal Psychology Vol. 120 Iss. 2 (2011) p. 272 - 285
Available at: http://works.bepress.com/sarah-sass/5/