This article demonstrates, by example, 2 approaches to the analysis of knowledge work. Both methods draw on network as a framework: a Latourian actor–network theory analysis and a network analysis. The shared object of analysis is a digital humanities and digital media research lab that is the outcome of the collective and coordinated efforts of researchers and other stakeholders at North Carolina State University. The authors show how the two methods are drawn to different objects of study, different data sources, and different assumptions about how data can be reduced and made understandable. The authors conclude by arguing that although these methods yield different outlooks on the same object, their findings are mutually informing.