A global public health emergency like the Coronavirus Infectious Disease 2019 (COVID-19) pandemic requires accurate and timely data collection in the research community. High impact research in science, technology, engineering, and mathematics (STEM) has been prioritized in the fight against COVID-19. The present study investigated the impact of COVID-19 on STEM research and the collaboration between global research institutions and industries. It was noted that COVID-19 had caused significant delays in non-COVID-19-related research projects and the onset of several remote studies. Most importantly, researchers in the STEM fields directed their attention and expertise to help mitigate virus transmission, treat patients, and implement appropriate public health interventions. Innovations are being integrated in several fields of technological and engineering research to provide optimal patient care and enhance physical distancing measures. Global research platforms are also designed to encourage accelerated research, especially in potential medicinal treatment. Collaboration amongst different disciplines and countries has enabled remarkable progress in the dissemination of scientific knowledge and appropriate responses to address the consequences of this pandemic on worldwide research in STEM.