Researcher and Institutional Review Board Chair Perspectives on Incidental Findings in Genomic ResearchGenetic testing and molecular biomarkers
NLM Title AbbreviationGenet Test Mol Biomarkers
DOI of Published Version10.1089/gtmb.2011.0248
AbstractAims: Genomic research can produce findings unrelated to a study's aims. The purpose of this study was to examine researcher and Institutional Review Board (IRB) chair perspectives on genomic incidental findings (GIFs). Methods: Nineteen genomic researchers and 34 IRB chairs from 42 institutions participated in semi-structured telephone interviews. Researchers and chairs described GIFs within their respective roles. Few had direct experience with disclosure of GIFs. Researchers favored policies where a case by case determination regarding whether GIF disclosure would be offered after discovery, whereas IRB chairs preferred policies where procedures for disclosure would be determined prior to approval of the research. Conclusions: Researcher and IRB chair perspectives on management of GIFs overlap, but each group provides a unique perspective on decisions regarding disclosure of GIFs in research. Engagement of both groups is essential in efforts to provide guidance for researchers and IRBs regarding disclosure of GIFs in research.
Journal Article VersionAccepted Manuscript
Published Article/Book CitationGenetic testing and molecular biomarkers, 16:6 (2012) pp.508-513. DOI:10.1089/gtmb.2011.0248.
RightsCopyright © Mary Ann Liebert, Inc., 2012. Posted by permission.
Citation InformationJanet K. Williams, Sandra Daack-Hirsch, Martha Driessnack, Nancy R Downing, et al.. "Researcher and Institutional Review Board Chair Perspectives on Incidental Findings in Genomic Research" Genetic testing and molecular biomarkers Vol. 16 Iss. 6 (2012) p. 508 - 513 ISSN: 1945-0257
Available at: http://works.bepress.com/sandra_daack-hirsch/48/