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Article
Testing the Differential Effects of Symptom Management Interventions in Cancer
Peer Reviewed Articles
  • Alla Sikorskii, Michigan State University
  • Charles W. Given, Michigan State University
  • Azfar-E-Alam Siddiqi, Michigan State University
  • Victoria Champion, Indiana University
  • Ruth McCorkle, Yale University
  • Sandra L. Spoelstra, Grand Valley State University
  • Barbara A. Given, Michigan State University
Publication Date
4-1-2014
Keywords
  • cancer,
  • oncology,
  • moderators,
  • symptom management,
  • age,
  • depression
Abstract

Objective: The purpose of this study was to test for moderating effects of patient characteristics on self-management interventions developed to address symptoms during cancer treatment. Patient’s age, education and depressive symptomatology were considered as potential moderators.

Methods: A secondary analysis of data of 782 patients from two randomized clinical trials was performed. Both trials enrolled patients with solid tumors undergoing chemotherapy. After completing baseline interviews, patients were randomized to a nurse-delivered intervention versus intervention delivered by a “coach” in trial I, and to a nurse-delivered intervention versus an intervention delivered by an automated voice response system in trial II. In each of the two trials, following a 6-contact 8-week intervention, patients were interviewed at week 10 to assess the primary outcome of symptom severity.

Results: While nurse-delivered intervention proved no better than the “coach” or automated system in lowering symptom severity, important differences in the intervention by age were found in both trials. Patients <45 years responded better to the “coach” or automated system; while those >75 years favored the nurse. Education and depressive symptomatology did not modify the intervention effects in either of the two trials. Depressive symptomatology had a significant main effect on symptom severity at week 10 in both trials (p=.03 and p<.01, respectively). Education was not associated with symptom severity over and above age and depressive symptomatology.

Conclusions: Clinicians need to carefully consider the age of the population when using or testing interventions to manage symptoms among cancer patients.

Comments

Original Citation:

Sikorskii, A., Given, C. W., Siddiqi, A.-E.-A., Champion, V., McCorkle, R., Spoelstra, S. L., & Given, B. A. (2015). Testing the Differential Effects of Symptom Management Interventions in Cancer. Psycho-Oncology, 24(1), 25–32. http://doi.org/10.1002/pon.3555
Citation Information
Alla Sikorskii, Charles W. Given, Azfar-E-Alam Siddiqi, Victoria Champion, et al.. "Testing the Differential Effects of Symptom Management Interventions in Cancer" (2014)
Available at: http://works.bepress.com/sandra-spoelstra/40/