Skip to main content
Article
A Randomized Controlled Trial of the Feasibility and Preliminary Efficacy of a Texting Intervention on Medication Adherence in Adults Prescribed Oral Anti-Cancer Agents: Study Protocol
Peer Reviewed Articles
  • Sandra L. Spoelstra, Grand Valley State University
  • Charles W. Given, Michigan State University
  • Alla Sikorskii, Michigan State University
  • Constantinos K. Coursaris, Michigan State University
  • Atreyee Majumder, Michigan State University
  • Tracy DeKoekkoek, Michigan State University
  • Monica Schueller, Michigan State University
  • Barbara A. Given, Michigan State University
Publication Date
6-23-2015
Keywords
  • cancer,
  • intervention,
  • medication adherence,
  • mHealth,
  • nursing,
  • oral anti-cancer agent,
  • randomized controlled trial,
  • recruitment,
  • text messaging
Abstract

Aim: The aim of this study was to report a study protocol that examines feasibility, preliminary efficacy and satisfaction of a text message intervention on the outcome of medication adherence in adult patients prescribed oral anti-cancer agents.

Background: Administration of oral anti-cancer agents occurs in the home setting, requiring patients to self-manage the regimen as prescribed. However, many barriers to medication adherence exist: regimens are often complex, with cycling of two or more medications; side effects of treatment; most cancer patients are older with comorbid conditions and competing demands; and cognitive decline and forgetfulness may occur. Research indicates patients miss nearly one-third of the prescribed oral anti-cancer agent dosages. Text message interventions have been shown to improve medication adherence in chronic conditions other than cancer. However, a majority of those patients were less than 50 years of age and most cancer patients are diagnosed later in life.

Design: A two-group randomized controlled trial with repeated measures.

Methods: Seventy-five adult patients newly prescribed an oral anti-cancer agent will be recruited (project funded in April 2013) from community cancer centres and a specialty pharmacy. Participants will be randomized to either a control group (n = 25; usual care) or an intervention group (n = 50; usual care plus text messages timed to medication regimen). Outcome measures include: medication adherence, feasibility and satisfaction with the intervention. Data will be collected over 8 weeks: baseline, weekly and exit.

Discussion: Standardized text message intervention protocol and detailed study procedures have been developed in this study to improve medication adherence.

Comments

Original Citation:

Spoelstra, S. L., Given, C. W., Sikorskii, A., Coursaris, C. K., Majumder, A., DeKoekkoek, T., … Given, B. A. (2015). A Randomized Controlled Trial of the Feasibility and Preliminary Efficacy of a Texting Intervention on Medication Adherence in Adults Prescribed Oral Anti-Cancer Agents: Study Protocol. Journal of Advanced Nursing, 71(12), 2965–2976. http://doi.org/10.1111/jan.12714

Citation Information
Sandra L. Spoelstra, Charles W. Given, Alla Sikorskii, Constantinos K. Coursaris, et al.. "A Randomized Controlled Trial of the Feasibility and Preliminary Efficacy of a Texting Intervention on Medication Adherence in Adults Prescribed Oral Anti-Cancer Agents: Study Protocol" (2015)
Available at: http://works.bepress.com/sandra-spoelstra/38/